Epigenetics and Diabetes Risk: Not Just for Imprinting Anymore? | Diabetes

http://diabetes.diabetesjournals.org/content/60/7/1859.long?trendmd-shared=0


この論文昔から張ってましたがようやくジャロさんも何を言いたいかわかってきたみたいですね
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In sum, methylation status of an RXRA promoter region was strongly correlated directly with childhood adiposity in two independent cohorts and inversely associated with early pregnancy carbohydrate intake in the initial cohort.
Taken together, these findings suggest that effects of the in utero environment on development influence later metabolic parameters via epigenetic gene-specific promoter methylation, possibly mediated through maternal diet.
That RXRA in particular emerged as a gene whereby methylation-modulated
expression is related to adiposity lends credence to the findings given the role of RXRA in dimerizing with PPARs, and in turn lipid and carbohydrate metabolism (21).