An extra-uterine system to physiologically support the extreme premature lamb [無断転載禁止]©2ch.net

**名無しゲノムのクローンさん** · 2017/04/28(金) 01:17:58.28

https://www.nature.com/articles/ncomms15112

**名無しゲノムのクローンさん** · 2017/04/28(金) 01:19:24.26

Abstract

In the developed world, extreme prematurity is the leading cause of neonatal mortality
and morbidity due to a combination of organ immaturity and iatrogenic injury. Until now,
efforts to extend gestation using extracorporeal systems have achieved limited success.
Here we report the development of a system that incorporates a pumpless oxygenator circuit
connected to the fetus of a lamb via an umbilical cord interface that is maintained within a
closed ‘amniotic fluid’ circuit that closely reproduces the environment of the womb.
We show that fetal lambs that are developmentally equivalent to the extreme premature human
infant can be physiologically supported in this extra-uterine device for up to 4 weeks.
Lambs on support maintain stable haemodynamics, have normal blood gas and oxygenation
parameters and maintain patency of the fetal circulation. With appropriate nutritional
support, lambs on the system demonstrate normal somatic growth, lung maturation and brain
growth and myelination.