Pre-clinical data are ambiguous. Some show a reduction of tumor.
Yet some in vitro as in vivo experiments, gave warnings as to the safety of this diet. In vitro data showed that cancer cells not only adapt to the situation but develop mutations
and characteristics of stem cells. One hypothesis is that the diet puts the tumor under stress and thus selects for resistance and malignancy.
In an experiment on mice, the tumors in the diet-treated group initially grew less but later tumor growth accelerated and exceeded that of the control group