In contrast, a later study reported that depletion of HP1α failed to produce mitotic defects in human
cells (Serrano et al., 2009 blue right-pointing triangle), casting doubts on the original report by Yamagishi et al.
In addition, our results presented here suggest that the centromeric pool of HP1 bound to INCENP cannot
physically interact with Sgo1. Our finding further questions the validity of the proposed, direct contribution
of HP1α in Sgo1 centromeric targeting during mitosis of human cells.